Oliguria after taking febuxostat may be caused by side effects of the drug, but also by decreased circulating blood volume, renal failure, urinary tract obstruction, etc. It is recommended to improve relevant examinations and early treatment. According to the results of pre-Febuxostat clinical studies, under a certain dosage of administration, urinary system adverse effects including kidney stones, renal failure, etc., may cause decreased urination. 1. Decrease in circulating blood volume: this can be seen after profuse sweating, severe vomiting and diarrhea, bleeding and other reasons leading to a decrease in the effective circulation of blood, and at the same time insufficient fluid supplementation, which may cause oliguria or even anuria, etc. It is recommended to go to the hospital in time for rehydration and symptomatic treatment in such cases. 2. Renal failure: the kidneys can not play a normal function, can not normally produce urine, serious cases can cause urinary or anuria, need to improve the renal function and other tests, you can follow the doctor’s instructions to improve renal function drugs, drugs to promote urination, etc., and dialysis or kidney transplantation under the guidance of the doctor, if necessary. 3. Urinary tract obstruction: After urine production due to urinary tract obstruction and can not be discharged normally, can be seen in the urinary tract of the stones, tumors and other conditions, improve the urinary tract imaging examination, can be under the guidance of the doctor lithotripsy or surgical treatment. If oliguria occurs during the administration of febuxostat, it is recommended to immediately go to the hospital, if it is determined to be caused by the drug, adjust the drug under the guidance of the doctor; if it is not caused by the drug, it is also necessary to investigate the cause of the disease in time, and standardize the treatment as soon as possible.