The essence of muscle pressure pain is an aseptic inflammatory condition that manifests itself primarily as pressure, pain, and dysfunction in the affected area. Muscle pressure pain occurs in the muscles that innervate hyperactive or weight-bearing joints or in the muscles or ligaments that hold these joints together, especially at the point of attachment of the muscle or ligament to the bone. Prolonged and frequent repetition of a particular movement is a common cause of overload use. Here is how to make a good differential diagnosis of muscle pressure pain. 1, sore limbs after alcohol Alcohol overdose can stimulate various organs of the body to produce acid toxicity, especially first in the muscles produced by a large amount of creatine and lactic acid leading to muscle soreness in the limbs muscle soreness throughout the body and a swollen feeling very weak and uncomfortable. 2, muscle tension pain Muscle tension pain is a clinical manifestation of neurasthenia. Neurosis is a neurological disorder based on the weakening of brain and somatic functions. It is characterized by easy mental excitement and fatigue, often accompanied by emotional symptoms such as tension, worry, irritability and muscle tension pain, sleep disorders and other symptoms of physiological dysfunction. 3. Acute infectious myositis Acute infectious myositis is often secondary to influenza and other respiratory infections and manifests as severe symmetrical muscle pain and weakness, which can be completely relieved within a few days after rest. There are no EMG or muscle biopsy abnormalities except for elevated muscle enzymes. 4. Mixed connective tissue disease Patients have non-depressed puffiness of the face and hands, salami-like swelling of the fingers, fever, non-destructive polyarthritis, muscle weakness or myalgia, and other symptoms. Antibodies to both leaching nuclear antigen (ENA) and RNP may be high titer positive.