For patients with nodular hyperplasia of the liver, first of all the patient needs to clarify whether there is viral hepatitis or not. If the patient is a viral hepatitis patient with nodular hyperplasia of the liver, the patient needs to have blood drawn to check for alpha-fetoprotein to see if it is elevated. In addition, blood should be drawn for hepatitis B DNA, hepatitis C RNA and liver function. If the virus replication is indicated and the liver function is combined with the elevation of glutathione and ghrelin, it is considered that the virus replication is in the window phase and the patient needs further antiviral treatment and active liver protection therapy. If the patient has been checked for 3 times in a row, all of them suggest elevated fetoprotein, then the patient needs to further check the enhanced CT and MRI of the upper abdomen. After the above examinations, the nature of the nodular hyperplasia of the liver can be clinically diagnosed and the possibility of liver tumor disease can be detected. If necessary, liver aspiration biopsy is also needed. After liver aspiration biopsy, the diagnosis can be confirmed by pathology. If the patient suggests a neoplastic disease of the liver, early treatment can be performed. For smaller liver tumors, radiofrequency ablation of liver masses under ultrasound guidance can be considered, and for larger masses, surgery is the preferred treatment if it is possible.