Endometrial cancer is now considered to be one of the gynecologic manifestations of a disease called “metabolic syndrome”. Metabolic syndrome is a group of disease syndromes with obesity as the main manifestation, including hypertension, diabetes, and hyperlipidemia. Therefore, it is possible to prevent endometrial cancer by making lifestyle changes or by controlling these diseases with certain medications. It is still difficult to prevent endometrial cancer 100%. However, taking measures to address the high-risk factors of endometrial cancer can reduce the occurrence of endometrial cancer, or at least achieve early diagnosis and treatment of endometrial cancer and reduce the mortality rate. Carry out cancer prevention publicity and screening, and strengthen medical knowledge education Women should pay special attention to abnormal vaginal bleeding, postmenopausal bleeding and abnormal vaginal fluid discharge; women with combined obesity, hypertension or diabetes should be more alert and seek medical treatment in time when problems are detected. Maintain ideal weight Given the close relationship between endometrial cancer and diabetes, hypertension and obesity, a healthy lifestyle and maintaining ideal weight is a very economical and efficient measure to prevent endometrial lesions. Identify the cause of abnormal menopausal bleeding Women with abnormal menopausal bleeding should not preconceive that it is dysfunctional uterine bleeding caused by the disruption of sex hormone secretion as women age and start long-term endocrine therapy, but should figure out the cause of the bleeding. If abnormal echogenicity of the endometrium is detected by ultrasonography or other imaging examinations, diagnostic curettage is required to remove the endometrium for pathological examination and rule out malignant endometrial lesions before starting treatment. Timely treatment of precancerous endometrial lesions Patients with endometrial hyperplasia, especially atypical hyperplasia, should be actively treated and closely followed up. If the treatment is not effective, the uterus should be surgically removed in time. If the patient has children, or has no hope of having children, or is older, it is not necessary to insist on conservative treatment, and removal of the uterus is appropriate. Although the uterus is very important to women, it is worth removing it in comparison to the occurrence of cancer. Strictly control the indications for estrogen use When using estrogen for replacement therapy in menopausal women with menstruation, progestin should be added to protect the endometrium, and close monitoring should be performed.