High signal in the white matter of the brain is an imaging term that refers to patients who show some highlighted signal on the T2 sequence or FLAIR sequence when they have an MRI. As we age, the white matter of the brain will undergo degenerative changes, especially ischemic changes, generally to the age of 40 or more people will have a little bit of the white matter of the brain slightly high signal number, so the appearance of a slightly high signal do not need to be nervous, is a normal physiological phenomenon, the cause of age, risk factors, as follows: 1, age: the largest possible age-related, the older the age, the more likely to appear white matter of the brain high signal 2, risk factors: there are also some risk factors, such as hypertension, hyperlipidemia, diabetes, smoking, these factors can lead to small blood vessel lesions in the white matter of the brain leading to ischemia, which can also appear slightly high signal in the imaging.