Chest and axillary pain can be seen in patients with breast hyperplasia. The pain may be accompanied by chest tightness or palpitations, especially in middle-aged patients, and may be triggered by pre-menstrual period, emotional fluctuations, and exertion. Oral Chinese medicines can be used to regulate the symptoms, and the symptoms can be gradually improved. In addition, chest wall diseases or thoracic mediastinal space-occupying lesions can also cause localized pain. Chest CT examination can further confirm the diagnosis, for occupying changes, if necessary, further surgical treatment is also needed, trauma after the chest wall soft tissue contusion, complication of intrapulmonary infection, is also prone to chest pain, timely immobilization and anti-infective treatment, the patient’s pain symptoms can be gradually reduced.