Hypopigmented myxoid granuloma includes multiple forms of skin damage, enlarged lymph nodes, cancerous malignancy and other hazards, which should be treated as early as possible with standardized treatment and regular review. Hypopigmented myxoid granuloma is a kind of low malignant cutaneous T-cell lymphoma, which mainly manifests in various forms of erythema and skin infiltrative damage, and the disease may change from scaly plaque to myxoid granuloma according to the different course of erythema, plaque, and tumor stages. It presents the hazards of itchy skin, affecting aesthetics and so on. Secondly the disease, as a lymphoma, involves the lymphatic immune system, which can lead to enlargement of the lymph nodes. In the tumor stage of hypopigmented mycosis fungoides, the cancer cells also invade the normal cells of the body. Although the disease has a slower clinical course than other malignant tumors, it is important to consult a doctor in a timely manner in order to remove the lesions and prolong the disease-free survival rate, so as to prevent the disease from progressing and endangering the life and health of the patient.