All kinds of antihypertensive drugs have side effects, the main side effects are manifested in the following aspects: 1. diuretics. The main side effects of these drugs can cause electrolyte disorders, especially hypokalemia, and may also cause elevated uric acid and elevated blood lipids. 2, beta-receptor antagonists. Commonly used drugs such as metoprolol extended-release tablets, bisoprolol, carvedilol, etc. Common major side effects include severe bradycardia, heart failure in patients with heart failure may worsen heart failure, asthma patients may aggravate respiratory distress. 3, angiotensin-converting enzyme inhibitors. The most common drugs such as Benadryl, the main side effects of this drug include hyperkalemia, angioedema, irritating dry cough, etc. If the cough is more severe, this can also be replaced with temisartan. 4, calcium antagonists, the main side effects include headache, facial redness and edema of the lower limbs.