Currently, the incidence of hyperlipidemia is increasing rapidly, and many patients are often seen in outpatient clinics for lipid screening. Many patients still have misconceptions about lipids. The four lipid tests are the main components of the test. They include: total cholesterol, triglycerides, LDL, and HDL. The age of the patients varies from those who simply have elevated lipids and fatty liver to those who have underlying diseases such as hypertension, diabetes, cerebrovascular disease, and hypothyroidism. Patients often compare their lipid levels with the reference values when they get their labs, and if they are within the reference values, they think they can stop the medication. In fact, whether to stop the medication or not should be related to the characteristics of the patient’s condition. Hyperlipidemia is the main risk factor for atherosclerosis, mainly low-density lipoprotein. The decision to adhere to the medication and to reduce or stop the medication is based on the presence of risk factors for atherosclerosis and the presence of atherosclerosis and plaque. All commonly used lipid-lowering drugs have certain side effects and should be selected according to the characteristics of the patient’s condition. Individualized treatment should also be implemented for hyperlipidemia. Of course, diet and exercise are always the basis of treatment.