The occurrence of gastric sinus erosion is considered to be related to Helicobacter pylori infection, long-term use of certain medications, and gastroduodenal reflux. 1. Helicobacter pylori infection: Helicobacter pylori infection, especially colonized in the gastric sinus, will form an inflammatory reaction of the gastric sinus, causing mucosal erosion and ulceration. 2. Long-term use of certain drugs: long-term use of non-steroidal anti-inflammatory drugs (e.g., aspirin), antibiotics (e.g., amoxicillin), anticancer drugs (e.g., methotrexate), etc., which can stimulate the mucous membrane of the sinus, appearing in the gastric sinus erosion. 3. Gastroduodenal reflux: when the pyloric portals connecting the stomach and duodenum are relaxed, duodenal fluid and bile can be caused to reflux back into the gastric sinus, resulting in inflammation and erosion of the mucosa of the gastric sinus. Gastric sinus erosion may also be related to other causes, it is recommended to consult a doctor in a timely manner, under the guidance of a professional physician to clarify the cause of the disease, and standardized treatment.