Liver puncture G3S3 indicates that the liver has moderate inflammation with fibrosis but no cirrhosis. Liver puncture pathology is one of the most important bases for making a clear diagnosis, measuring the activity of inflammation and the degree of fibrosis, and determining the efficacy of drugs, in which the inflammatory grading of liver tissue is based on necrosis and inflammation to assess the degree of liver lesions, which is denoted by G; and the fibrosis staging is based on the degree of fibrosis and the formation of cirrhosis to measure the disease, which is denoted by S. According to the chronic hepatitis grading and staging criteria, there are 5 grades and 5 stages, in which G0S0 represents no inflammation and no fibrosis, G4S4 represents severe inflammation and necrosis with cirrhosis, and G3S3 indicates that the liver has moderate inflammation with fibrosis (fibrous septa with lobular structural disturbances), but no cirrhosis. If the liver puncture suggests G3S3, you should consult the doctor in time and standardize the treatment under the doctor’s guidance, and reasonable treatment can effectively slow down the progress of the disease.