A blister on the glans is recommended to go to the hospital for a relevant examination to clarify the cause and then eliminate the symptoms. First, if there is excessive frequent masturbation or mechanical friction, it is recommended to stop the relevant stimulation and use iodophor swabs for local disinfection, 2-3 times a day the blisters can gradually subside. Secondly, if there is glansitis, there can be local infectious blisters which can develop into pus blisters. If you have a bacterial infection, it is recommended to apply a little topical Bactrim ointment 3 times a day for 3-5 days to observe the elimination of blisters. If there is a fungal infection causing small herpes-like changes, it is recommended to use sodium bicarbonate solution for local topical cleansing. After the topical cleansing, apply a little clotrimazole ointment 3 times a day for a week. Third, if the herpes virus infection is caused, it is recommended to take one oral acyclovir capsule 3 times a day for 10 days and apply a little topical acyclovir ointment 3-4 times a day for a week.