For patients in coma with very many causes, the main protocols to promote waking are as follows. Hyperbaric oxygen chamber treatment, at least 24 hours to maintain normal breathing, oxygen, passive movement of limb joints, patting, alternating hot and cold water stimulation, bilateral low frequency electrical stimulation of the median nerve, then is a gentle call, play the music or radio that the patient likes to listen to, the voice of friends and relatives is effective to some extent. Attention should be paid to the prevention of infection and thrombotic complications, targeted to promote awakening can use certain drugs to play a facilitating role. For example, naloxone, bromocriptine, medroxyprogesterone, neurojunctional glycosides, etc. Pay attention to monitoring liver and kidney function and keep a follow-up.