The specific methods to wake up comatose patients are: 1) hyperbaric oxygen therapy: early patients should do it at least dozens of times; 2) passive activities: passive movements of the joints of the patient’s limbs; 3) promotion of nerve activity: patting, alternating hot and cold water stimulation, low-frequency electrical stimulation of nerves; 4) external stimulation: relatives calling, playing the patient’s favorite music, etc.; 5) medication: taking drugs that nourish the brain nerves; please combine the specific medication with the clinical situation, subject to the guidance of the doctor’s interview.