Comatose patients often have impaired sputum elimination because of central respiratory impairment, which leads to their respiratory failure, increased airway secretions, and weakened cough reflexes, and patients often develop pneumonic pneumonia and aspiration pneumonia. For such patients, they should be given nebulized inhalation, and the nebulized drugs that can be used are amiloride and chymotrypsin, which help to humidify the airway, dilute the sputum, make it less likely to form sputum crusts, and make it easier to eliminate. The patient can also be given a nurse to perform vibratory sputum evacuation, twice a day, to promote the outward movement of sputum from the deeper parts. At the same time, antibiotics should be used, and based on the results of sputum culture and drug sensitivity, a regular course of targeted antibiotics should be selected, usually for at least 7-14 days, and antibiotics should be discontinued only after the patient’s sputum culture has turned negative.