Severe atrophic gastritis belongs to the more serious gastritis, atrophic gastritis combined with Helicobacter pylori infection needs to use quadruple therapy, atrophic gastritis combined with erosive ulcers can be applied with acid-suppressing medicines and mucosal protective agents. 1. Atrophic gastritis combined with Helicobacter pylori infection can be treated with antibiotics, combined with proton pump inhibitors and bismuth eradication. Such as amoxicillin, metronidazole combined with omeprazole, bismuth potassium citrate and so on. 2. Atrophic gastritis combined with erosive ulcers can apply acid inhibitors and mucosal protectants, acid inhibitors including proton pump inhibitors (such as omeprazole, lansoprazole, etc.) and H2 receptor antagonists (such as ranitidine, famotidine, etc.), gastric mucosal protectants are common drugs such as aluminum thioglycollate, bismuth potassium citrate, colloidal bismuth pectin, and so on. In the treatment of severe atrophic gastritis, we must strictly follow the doctor’s instructions for medication, not blindly self-medication, and avoid the use of drugs that have damage to the gastric mucosa, such as aspirin, erythromycin, etc., so as not to aggravate the condition.