Lung failure coma in advanced stage of lung cancer can be treated by general treatment, drug treatment and so on. 1. General treatment The main treatment is low concentration and low flow rate of oxygen to avoid the deterioration of the disease caused by high concentration of oxygen; in case of respiratory failure, it is feasible to connect respirator with endotracheal intubation, etc.; to maintain the vital signs stable; to maintain the balance of electrolyte and acid-base, and to keep the supply of body’s calorie and nutrients. 2.Drug treatment If there is a combination of central nervous system lesions, mannitol, dehydration and other drugs can be used for treatment; if necessary, coenzyme A, cytochrome C and other drugs can be used in combination to provide energy for the brain cells to maintain the normal function of brain cells. At the same time, the treatment of excited breathing and heart rate control can be given according to the patient’s condition, and if the patient’s blood pressure decreases progressively, the treatment of blood pressure elevation can be given and so on. If lung cancer advanced lung failure coma, the prognosis is very poor, one should seek medical treatment in time, and related drugs should be used under the guidance of doctor.