Women should think of the following kinds of diseases when they have nipple discharge: I. Intraductal papilloma: This disease can discharge bloody fluid (usually bright red) from the red head when the areola is lightly pressed. It occurs spontaneously in middle-aged and old women aged 40 to 50 years, and malignant changes occur in about 6% to 8% of cases. Breast cystic hyperplasia: the nipple discharge from the cysts around the milk ducts, the discharge is mostly yellow-green, brown or bloody fluid, occasionally colorless plasma, about 2% to 3% of the cases of this disease occur malignant changes. Intraductal tumor: the disease often spills bloody fluid from the nipple, and cancer cells can be found in smear examination. Childbirth or pregnancy: the mammary glands of these women are congested with blood, which makes them easy to bleed in the ducts or in the breast tissues, and the blood overflows from the ducts through the nipples, and such overflow is mostly a normal physiological phenomenon. In addition, women with ductal inflammation or taking estrogen will also have nipple overflow, which is mostly yellow watery plasma secretion, and the epithelial cells can be seen in the smear with double nuclei, multiple nuclei, large nuclei, obvious cell stratification, and leukocytes invading into the epithelial cells and other manifestations. To summarize, when the middle-aged and elderly women appear red head overflow should be doubly vigilant, should quickly go to the hospital for smear examination, in order to make a correct diagnosis in time, early treatment.