Primary hand sweating is a phytodysfunctional disorder that is common in young people in subtropical regions and affects approximately 0.6-1.0% of the population. The mechanism is not yet known. Patients usually begin to experience symptoms at an early age or during adolescence, and they remain with the disease for life. The disease is mild and does not require treatment. In more severe cases with a tendency to get progressively worse, the sweat may drip continuously along the fingers, especially during stress, emotional stress, fear, anxiety, or anger, so it is also called psychogenic hyperhidrosis. Sweating can be continuous or intermittent and is triggered by anxiety, stress or fear. Although there is no direct impact on health, it can seriously affect the patient’s work, study, life, and social life. Patients are afraid to shake hands with others, and their writing paper is soaked with sweaty hands, which brings great inconvenience to their work and life. Most patients come to the doctor with a depressed, low self-esteem attitude. Although there are many treatments available for hand sweating, most of them are not effective. The most common include oral sedatives, anticholinergic drugs, and subcutaneous injections of botulinum toxin A. These methods have not been promoted because of their side effects and inaccurate efficacy. There are also TCM herbal lotions, antiperspirants, oral medications, and biofeedback treatments, but they are often ineffective. In 1992, Landrenesu was the first to successfully treat hand sweating with televised thoracoscopic partial sympathetic nerve chain excision. Thoracoscopic partial sympathetic nerve chain resection is suitable for severe upper extremity hyperhidrosis in which other treatments have failed. The accuracy of thoracoscopic surgery is greatly improved with the help of camera technology, especially the magnified images it provides. The effectiveness and safety of T2-4 sympathetic nerve trunk dissection through 5mm and 10mm thoracoscopy for the treatment of hand sweating has been clinically proven over the past decade or so with the rapid development of thoracoscopic surgical techniques. Thoracoscopic surgery for hand sweating has been widely used in clinical practice because of its minimally invasive, safe and effective advantages. With the maturity of thoracoscopic surgery and the depth of clinical research, thoracic sympathetic nerve trunk dissection has been gradually replaced by 2-incision surgery from the initial 3-incision surgery, and the surgical efficacy has been improved and the surgical trauma has been reduced. At present, most medical centers in China use 10mm, 5mm or 1.7mm pinhole type thoracoscopes and instruments to perform thoracic sympathetic nerve trunk dissection using three or two incision surgery. The important feature of our hospital is the use of axillary 1cm, single-hole method and operable thoracoscope for surgery, which reduces postoperative pain and shortens the hospital stay (average hospital stay of three days), further satisfying patients’ demand for “Minimally invasive” and “cosmetic” requirements (the small 1cm axillary incision is almost invisible after healing). Postoperative complications of TV thoracoscopic partial sympathetic chain resection include Homer’S syndrome, compensatory hyperhidrosis (compensatory weating, CS) in areas other than both upper extremities (trunk), pneumothorax, hemothorax, pulmonary atelectasis, lung infection, and pain. We have not experienced complications such as Homer’s syndrome, pneumothorax, hemothorax, pulmonary atelectasis, or lung infection. Only a few patients experienced compensatory hyperhidrosis in areas other than the upper extremities, but the symptoms were mostly mild, and the compensatory sweating did not adversely affect the patients’ daily life, work, or study, and most of them healed spontaneously after six months. In our review of patients with hand-foot hyperhidrosis admitted to our hospital, our findings confirm that single-port thoracoscopic bilateral T2-4 sympathetic nerve trunk dissection is safe and effective in the treatment of hand-foot hyperhidrosis.