Esophageal cancer, or esophageal cancer, is a malignant tumor that occurs in the mucosal epithelium of the esophagus. The symptoms of patients in the first three days of advanced stage vary from person to person, and there are usually more than 8 common main symptoms, mainly including typical symptoms and concomitant symptoms. Patients are suggested to put their mind at ease to help relieve discomfort and pain to a certain extent.1. Typical symptoms: Typical symptoms of advanced esophageal cancer three days before death mainly include difficulty in eating, spitting mucus sputum and other symptoms, as well as systemic symptoms such as pain in various parts of the body. If there is difficulty in swallowing, semi-liquid or liquid diet can be given priority. For patients who cannot eat at all, highly nutritious liquid can be injected intravenously to ensure that the patient’s organism takes enough energy daily. For pain symptoms, painkillers can be applied according to the situation to help relieve the patient’s pain; 2. Accompanying symptoms: there can also be physical wasting, chest pain, nausea, vomiting, weakness, pressure sores, abnormal vital signs, emotional abnormalities, coma, peritoneal effusion, jaundice and other accompanying symptoms. In case of pressure sores, the patient should be assisted to turn regularly and change the resting position to avoid prolonged local pressure, and appropriate massage can also be applied to the pressure area. The patient’s family and companions should also focus on alleviating the patient’s pain and improving the quality of life as the main principles of end-of-life care, and should pay attention to providing adequate psychological support to the patient, communicating more with the patient and reassuring him/her, which can help alleviate the negative emotions such as pessimism, fear and anorexia. In addition, the patient’s family members also need to control their own emotions appropriately so as not to aggravate the patient’s bad mood and make the patient pass away with dignity and comfort.