Adapalene gel from different manufacturers does not, in principle, differ much in terms of therapeutic effect. Adapalene gel produced by different manufacturers has the same main ingredient, which is adapalene, a retinoid compound, the drug has an anti-inflammatory as well as a keratolytic effect, so it can be used in clinical practice for the treatment of pimples, as well as for the treatment of common acne. The main adverse effects of adapalene gel include localized skin erythema, burning, scaling, dryness, itching, etc., which can generally be tolerated, and for persistent or worsening signs of adverse effects, the medication must be discontinued in a timely manner. In the choice of adapalene gel treatment, the key is to choose the drugs produced by the regular manufacturers, follow the doctor’s instructions to use the drug, do not blindly use the drug, so as not to cause adverse consequences.