According to WHO, more than 70% of the world’s patients in the middle and late stages of cancer are suffering from different degrees of cancer pain, which greatly affects the quality of life of patients in the middle and late stages of cancer. In order to better relieve the pain of patients in the middle and late stages of cancer, medical practitioners around the world are actively working to find the best solution. From February 2004 to December 2008, we tried to add compound bitter ginseng injection to the conventional treatment for patients with mid- to late-stage cancer in order to solve cancer pain in patients with mid- to late-stage cancer. Better curative effect was achieved. 1. Clinical data: A total of 62 cases were collected for this group of observation. The patients were expected to survive for more than 3 months. All were patients who were hospitalized in our hospital from 2004 to August 2008. Randomly divided into treatment and control groups. Gender: Treatment group: 27 males and 5 females. Control group: 25 males and 5 females. Age: The treatment group was 61-80 years old, with an average age of 71 years. The control group was 60-80 years old, with an average age of 70 years. There were 14 cases of gastric cancer, 10 cases of intestinal cancer, and 8 cases of liver cancer in the treatment group; 15 cases of gastric cancer, 8 cases of intestinal cancer, and 7 cases of liver cancer in the control group. All cases were advanced cancer patients aged 60 years or older. The case profiles of the two groups were similar and comparable. 2. Treatment methods Both groups were treated with conventional pain medication according to the three-step pain relief method. The treatment group was randomly grouped and given compound bitter ginseng (Yanshu) injection (produced by Shanxi Jinjing Manufacturing Co., Ltd., each 5ml. containing 9g of raw herbs) 20ml, plus 5% glucose injection 250ml, intravenously, once a day for 20 days. Those who have achieved CR…PR can continue to apply 3 courses of treatment. Blood routine, liver and kidney function and electrocardiogram were tested before and after treatment and during treatment. 3.Efficacy evaluation criteria and results. (1) Pain grading: numerical assessment of pain grading method (NRS method) was used, with 0 being no pain, 1-3 being mild pain, 4-6 being moderate pain, and 7-10 being severe pain. All patients in this group were selected as patients with severe pain. (2), efficacy assessment: complete remission (CR): complete pain relief after treatment. Partial remission (PR): pain was significantly relieved compared with that before treatment. Mild remission (MR): pain was reduced compared with that before treatment. No remission (NR): no reduction compared with before treatment. Patients’ side effects before and after medication were also recorded. Partial remission and mild remission were considered valid cases. For statistical processing, SPSSI0.0 statistical software was applied and X2 test was used. (3), Results: Treatment group: CR 0 cases; PR 19 cases; MR 10 cases; NR 3 cases, total effective rate 90.6%. Control group: CR 0 cases; PR 14 cases; MR 10 cases; NR 6 cases, total effective rate 80 ％. Statistical treatment, P<0.05. (4) Side effects: No local and systemic side effects were observed during the treatment. There were no abnormalities in blood routine, heart, liver and kidney functions before and after treatment. 4.Discussion: Compound bitter ginseng injection is made of bitter ginseng and other Chinese herbs processed by modern technology. Experimental research shows that compound bitter ginseng injection has no obvious effect on protein and ribonucleic acid biosynthesis of cells, while it has obvious inhibitory effect on deoxyribonucleic acid biosynthesis, thus proving that it has certain anti-cancer effect. It has also been shown that compound bitter ginseng injection has enhanced the immune function of B lymphocytes and T lymphocytes, thus enhancing both humoral and cellular immune functions of the body and exerting anti-cancer effects. It has a proliferation inhibitory effect on tumor-inducing vascular endothelial cells. It can cause apoptosis of tumor cells. Compound bitter ginseng injection was recorded by hot plate method and acid stimulation twisting method to show that it has obvious analgesic effect, the intensity is similar to that of dulcolax, and the effect is very obvious. The test results by electric stimulation method showed that the pain threshold of mice could be significantly increased, so it has certain efficacy on mild to moderate pain caused by cancer. From the results of our study, compound bitter ginseng injection has good pain relief effect on patients with moderate to severe cancer pain, but it needs to be combined with conventional analgesic drugs. The drug has no adverse effects on important organs such as heart, liver and kidney. It is safe and effective. It is an ideal Chinese medicine for treating tumor patients to improve their pain symptoms. It is worth promoting its application in clinical practice.