The reason for high gastrin-releasing peptide precursor may be that the subject has cancer or there may be other reasons such as renal insufficiency. Gastrin-releasing peptide is a gastrointestinal hormone that promotes gastrin release. Gastrin-releasing peptide precursor is a precursor structure encoded by the gastrin-releasing peptide gene, which can be stably expressed in plasma and can represent gastrin-releasing peptide and gene expression. The reference value of serum gastrin-releasing peptide precursor is:0-68.3pg/mL. 1.Cancer: Gastrin-releasing peptide precursor is currently the preferred sensitive tumor marker for small cell lung cancer. At present, it is mainly used for early diagnosis, efficacy evaluation, disease monitoring and prognosis assessment of small cell lung cancer. Only the high level of gastrin-releasing peptide precursor does not confirm that the examinee is suffering from cancer, but should be viewed in conjunction with other examination indicators. For example, the combination of gastrin-releasing peptide precursor and pepsinogen Ⅰ and Ⅱ has high clinical significance in the diagnosis of gastric cancer; the joint detection of glycoantigen 125 and gastrin-releasing peptide precursor is helpful in the diagnosis of small-cell lung cancer and so on. 2. Renal insufficiency: gastrin-releasing peptide precursor may be elevated when creatinine concentration is 140μmol/L. Therefore, gastrin-releasing peptide precursor may be elevated. Therefore, high gastrin-releasing peptide precursor should also be considered as a possible cause of renal function factors. Gastrin-releasing peptide precursor abnormality, we need to improve the relevant examination in time, in order to clarify the cause of the disease early.