Organ failure refers to the state of loss of function of human organs due to various disease factors, and is the end state of organs, so there is no clear answer to the question of how old a person’s organs begin to fail. In general, the organ function of healthy adults gradually decreases with age, while the organ function decline and failure caused by disease can occur at any age. For example, acute organ failure is most often caused by serious disease-causing factors. For example, acute heart failure due to severe arrhythmia and heart attack, acute renal failure and brain failure due to shock, acute respiratory failure due to severe pneumonia, and acute liver failure due to poisoning. Chronic organ failure is mostly caused by the disease of the organ itself, with the progress of the disease, the organ function is gradually lost, such as chronic heart failure, chronic renal failure, etc.. The above-mentioned acute and chronic organ failure can be seen in children as well as in the elderly, and there is no fixed age at which the failure begins.