Myofibrillar pain syndrome belongs to rheumatic immune disease, with chronic pain in the whole body musculoskeletal as the main symptom, and its treatment includes general treatment, medication, psychotherapy and so on. 1. General treatment: patients should avoid exertion, pay attention to rest, improve sleep, appropriate activities, work and rest, while avoiding damp and cold environment. 2. Drug treatment (1) Analgesic drugs: non-opioid central analgesic drugs such as tramadol can be chosen. (2) Myorelaxant drugs: e.g. Eperisone, Cyclobenzaprine, etc. (3) Antidepressants: the first choice for the treatment of myofibrillar pain syndrome, such as amitriptyline, fluoxetine, duloxetine, etc., which can significantly relieve pain and improve the patient’s sleep. 3. Psychotherapy: such patients are prone to anxiety, tension, irritability and other emotions, and should be given adequate care and emotional guidance, so that the patient’s mood to relax and eliminate anxiety. Patients with myofibrillar pain syndrome are advised to go to the hospital in time for consultation and standardized treatment after a clear diagnosis. All of the above medications should be used under the guidance of a doctor, avoid self-medication.