Carotid plaque patients need to take long-term statin drugs to stabilize plaque and slow down plaque progression, but it is difficult to eliminate the plaque that has already formed, so it is generally necessary to take statin drugs for life. Carotid plaque is carotid atheromatous plaque, which is formed by lipid deposition after endothelial damage. Once a carotid plaque is formed, it is necessary to take statins (e.g., simvastatin, atorvastatin, etc.) for life to reduce blood lipids and stabilize the plaque, slow down the progression of the plaque and reduce the risk of plaque rupture, but it is very difficult to eliminate the plaque that has already been formed. Statins may cause nausea, elevated transaminases, myalgia, myositis and other discomforts, and discontinuation of the drug is usually not recommended in the absence of significant adverse effects. In addition, patients with carotid atheromatous plaques should also pay attention to adjusting their dietary habits, daily routine, pay attention to quit smoking and alcohol, eat less high-fat food, avoid staying up late and so on. Specific medication should follow the doctor’s instructions.