Syphilis can be categorized into stage 1 syphilis, stage 2 syphilis and stage 3 syphilis according to the course of the disease, and each stage has different symptoms. Stage 1 syphilis is characterized by a hard chancre and swollen lymph nodes, stage 2 syphilis is characterized by a syphilitic rash and flat warts, and stage 3 syphilis is characterized by skin and mucous membrane lesions and skeletal syphilis. 1. Stage 1 syphilis: it often starts to develop about 2-3 weeks after infection, and there are usually no systemic symptoms, mainly manifested as chancre and swollen lymph nodes, and small red spots may appear on the labia, perineum and uterine openings of females, without any self-consciousness. 2. Stage 2 syphilis: Syphilis rash often appears 3-4 weeks after the noma has subsided, covering the skin and mucous membranes of the whole body with red or reddish-brown papules, maculopapules and plaques, which are usually not itchy or mildly itchy. Some patients may develop pustules and ulcers. Flat warts, which are oval and irregularly shaped papules with a smooth textured surface, can also appear. When syphilis spreads to the whole body, it can lead to patchy hair loss, muscle aches and pains, swollen joints, fever, and vision loss. 3. Stage III syphilis: untreated or inadequate treatment of stage I and II syphilis can lead to stage III syphilis after 3 to 4 years. It can be manifested as permanent skin and mucous membrane damage, and can invade bones, heart and nervous system. When the above abnormal performance, need to go to the hospital in time.