0.6 cm gastric mesenchymal tumor is a small mesenchymal tumor, the specific need for surgery should refer to the site of gastric mesenchymal tumor, ultrasound endoscopy results and tumor follow-up changes. Gastric mesenchymal tumor is a kind of gastrointestinal mesenchymal tumor, which occurs in the stomach and originates from mesenchymal tissues. It is a non-epithelial and less malignant tumor, which usually manifests with symptoms such as abdominal distension, vomiting of blood, black stools, etc., and some people do not have any special reaction. Generally, 0.6 cm gastric mesenchymal tumor does not require surgery, and follow-up observation is sufficient. However, during ultrasound endoscopy, once the 0.6 cm gastric mesenchymal tumor is found to have irregular margins, uneven internal echogenicity, or liquid dark areas, it should be treated with surgery as soon as possible. If the gastric mesothelioma is found to have a tendency to grow and become larger during follow-up, it is recommended to go to the gastroenterology department or gastrointestinal oncology department of a regular hospital as soon as possible to clarify whether surgical treatment is needed. Therefore, the treatment of gastrointestinal mesenchymal tumors is based on the principle of individualized comprehensive treatment, according to the specific conditions of the patient’s tumor, comprehensive treatment, the most substantial eradication of the tumor and improve the cure rate. Normally, we should change the bad lifestyle and dietary habits, have three regular meals, eat in moderation, do not smoke, do not drink.