Spinal cord disease pressing on the nerve line usually refers to neuralgia caused by compression of the spinal cord or nerve roots, which can be treated with medication, surgery and physical therapy to relieve leg pain symptoms. 1. Medication: Neurotrophic drugs such as vitamin B1 tablets and methylcobalamin tablets can be taken under the guidance of specialized doctors to relieve the symptoms. 2. Surgery: Surgical methods such as decompression of spinal cord, stabilization and fixation of spine, correction of spinal deformity, etc. can be used to alleviate the symptoms. The necessity of surgery is usually considered according to the patient’s own condition and the degree of injury. Systematic examination should be conducted before surgery, and pre- and post-operative care should be well done. 3. Physiotherapy: Hyperbaric oxygen therapy and transcutaneous electrical nerve stimulation can be used. Hyperbaric oxygen therapy can improve the oxygen tension of the injured segment of the spinal cord and improve hypoxia. Transcutaneous electrical nerve stimulation therapy can improve the symptoms of nerve pain after spinal cord injury. If it is confirmed that the leg pain is caused by the compression of nerves by the spinal cord disease, it is necessary to pay attention to it and cooperate with the doctor for active treatment, so as to avoid further aggravation of the condition.