Thyroid nodule puncture is usually not considered painful. Thyroid nodule puncture is a procedure used to determine whether a nodule is benign or malignant. Thyroid nodule puncture requires local anesthesia, during the anesthesia process there may be mild pain, after the anesthesia and then the puncture is usually not painful, although after the anesthesia medicine has worn off there may be a certain degree of pain, but it is within the range of the patient’s ability to tolerate, so thyroid nodule puncture is generally not painful. After the nodule puncture, it is important to apply pressure to stop the bleeding and avoid contact with water to avoid infection. Patients who need to have a thyroid nodule puncture should actively cooperate with the doctor’s procedure.