Pancreatic islets usually do not have the ability to repair themselves. type 1 diabetes, acute pancreatitis, etc. lead to islet failure that cannot be self-healed. type 2 diabetes, if treated aggressively in the early stages, can control blood glucose and alleviate the symptoms to a certain extent. 1. Type 1 diabetes: immune-mediated destruction of pancreatic β-cells, resulting in islet failure and absolute insulin deficiency, usually requiring lifelong replacement therapy with insulin. A honeymoon period of partial recovery of islet function may occur when insulin is given early and intensively, but is of short duration. 2. Type 2 diabetes mellitus: hyperglycemia, relative lack of insulin, early insulin intensive therapy can control blood glucose levels to some extent, but with the development of the disease eventually islet function gradually decline. 3. Pancreatic injury: pancreatic injury caused by acute pancreatitis, partial resection of pancreatic tumor, etc., basically unable to restore islet function. It is recommended to go to the hospital in time to see a doctor if you find that your pancreatic islet function is declining, and to clarify the cause of the disease after completing the relevant examinations, and to carry out standardized treatment under the guidance of the doctor, so as to prevent further damage to the pancreatic islet function.