The situation of stomach pain in the middle of the night can be seen in a variety of reasons. 1, cold abdomen at night may cause stomach pain. 2, dinner if you eat too much, too fast, may also cause the situation of stomach pain at night. 3, the most common situation of stomach pain at night is most often seen in the duodenal ulcer. Duodenal ulcer manifestation is mainly when hunger pain, night pain, this is the duodenal ulcer is more unique pain manifestation, when there is a typical night pain symptoms, need to go to the hospital in time for examination, need to carry out gastroscopy examination, to clarify whether there is a duodenal ulcer. If the examination is clear duodenal ulcer, need to come to the formal treatment.