Patients with liver disease, whether benign or malignant, can have generalized weakness. This occurs because patients with liver disease, often in combination with varying degrees of liver dysfunction, can present with increased aminotransferases and jaundice. Patients with liver disease may have anorexia, loss of appetite, abdominal distension, nausea, vomiting, decreased food intake and emaciation, and the prolonged presence of these symptoms will cause the patient to develop generalized weakness. Due to the presence of long-term malnutrition, patients can develop anemia and hypoalbuminemia. Both anemia and hypoalbuminemia can manifest as weakness.