A study published in the American Journal of Neurology showed that older adults with high blood glucose or risk factors for diabetes are prone to develop the discolored material in the brain that causes progeria (Alzheimer’s disease). Therefore, it may be possible to prevent the development of Alzheimer’s disease by avoiding high blood sugar and preventing diabetes through proper diet and exercise. Toru Iwaki, a professor at Kyushu University in Japan, and others conducted a long-term follow-up survey of 135 residents of Kuyama town in Fukuoka Prefecture starting in 1988. The average age of these residents was 67 when the survey began, and all of them have been tested for blood glucose since then. They all died between 1998 and 2003, with an average life expectancy of 79.5 years. Sixteen percent of these 135 individuals developed progeria during the survey period. Autopsies of their remains revealed that 88 of them had intracerebral chromatophores. The researchers analyzed the relationship between high blood sugar and diabetes, etc. and intracerebral chromatophores according to the survey data, and finally confirmed that the risk of intracerebral chromatophores was 1.7 times higher in elderly people with high blood sugar compared to normal elderly people; and the risk of such chromatophores was 38 times higher in elderly people who not only had high blood sugar but also had genes that predisposed them to intracerebral chromatophores. Measures to prevent hyperglycemia and diabetes should also have a role in the prevention of progeria. This study demonstrates the fact that high blood sugar affects brain function. In fact, the effects of hyperglycemia go far beyond that. In the case of the brain, diabetics often have a combination of lacunar infarction, a type of brain infarction involving small arteries. Patients with multiple lacunar cerebral infarcts are prone to dementia. The adverse effects of hyperglycemia are a chronic process, even if they occur unknowingly. The study of diabetes in Daqing conducted by Prof. Guangwei Li is a rare and groundbreaking study of diabetes in China recognized by worldwide access. This study illustrated that lifestyle changes can reduce the incidence of diabetes. More than 20 years after the end of this study, the then hyperglycemic and normoglycemic population was returned. It was found that in the years more than 20 years after the DCH study, those who were then normoglycemic, died 22% of the time, while the mortality rate for the hyperglycemic population was 56%. This shows that the death rate of people with high blood sugar after more than 20 years was twice as high as that of people with normal blood sugar. Therefore, the harmfulness of hyperglycemia is a long-term chronic process, and it is not easy to manifest without a very long period of observation. Nowadays, we often encounter the situation that many young and middle-aged diabetic patients, do not pay attention to the control of risk factors such as hyperglycemia, hypertension and dyslipidemia. The reasons they give are lack of time, not feeling discomfort, etc. Unfortunately no feeling is not the same as no lesion, and chronic complications due to diabetes develop unknowingly.