Patients with vitiligo at the corners of the mouth may be able to make the white spots fade and achieve clinical cure after active and effective treatment, the specific efficacy varies from person to person. Vitiligo is a common pigment loss skin mucosal disease, the disease is stubborn and difficult to cure, and damage to the appearance of beauty, can bring great impact on life. Its treatment has some difficulties, but some patients can get better results after active and effective treatment, the main treatment methods include drugs, surgery, physical, masking treatment. Drug treatment includes topical drugs and oral drugs, commonly used topical drugs include fluticasone propionate ointment, tacrolimus ointment, carbotriol ointment, etc. Commonly used oral drugs are glucocorticosteroids such as prednisone, which have certain curative effects. Patients can also be physical therapy, mainly for a variety of phototherapy, if the white spots involved in the body surface area is too large, can also be considered masking treatment. In addition, for patients with stable vitiligo, surgical treatment can also be carried out, that is, transplantation therapy, including autologous epidermal sheet transplantation, tiny skin sheet transplantation and other methods, the procedure can be combined with phototherapy to improve the efficacy of treatment. As vitiligo is stubborn and difficult to treat, and recurrence may be, so the specific efficacy can not be generalized, the patient should be timely medical treatment, the professional doctor to formulate a reasonable treatment plan, do not blindly use their own medication, so as not to affect the condition.