Chronic non-atrophic gastritis with bile reflux is usually caused by bacterial infection, duodenal reflux, etc. It needs to be treated with gastric stimulants such as mosapride. 1. Gastric stimulants: Gastric stimulants such as domperidone and mosapride can be used to promote gastrointestinal peristalsis, thus facilitating the re-entry of refluxed bile into the intestinal tract and inhibiting more bile reflux. Gastric stimulants may have side effects such as diarrhea, abdominal pain, and dry mouth. 2. Drugs to inhibit gastric acid: chronic non-atrophic gastritis with bile reflux, the gastric mucosa is easily stimulated by gastric acid, can be used omeprazole and other acid-suppressing drugs to inhibit the secretion of gastric acid and reduce its stimulation of the gastric mucosa. Omeprazole may appear headache, rash, insomnia and other side effects. 3. Gastric mucous membrane protector: bile reflux needs to use gastric mucous membrane protector such as magnesium aluminum carbonate tablets to protect the gastric mucous membrane from bile and gastric acid, and strengthen the barrier effect of gastric mucous membrane. Magnesium aluminum carbonate tablets may appear constipation, dry mouth, loss of appetite and other side effects. When chronic non-atrophic gastritis with bile reflux occurs, it is necessary to go to the regular hospital in time for consultation and active treatment.