There is variability in the retention time of fillers for lines. At present, the common fillers are hyaluronic acid and autologous fat. Hyaluronic acid: the clinical effect of hyaluronic acid filler can generally last 6-8 months, the specific maintenance time is related to the molecular weight size and brand of hyaluronic acid; you can repeat the injection according to your own situation in order to maintain the long-term effect. Autologous fat: Autologous fat filler belongs to fat transplantation, when the transplanted fat becomes active, it is generally considered to be permanently active. The results are relatively long-lasting, lasting 3-5 years in most patients, and may last around 10 years for those with better maintenance. Considering the invasive nature of filler-based treatments and the richness of facial blood flow, there is a risk of embolization. If patients have the need to fill in the lines, it is recommended that they visit a regular medical institution and ask for the doctor’s guidance.