Babinski’s sign is examined by tracing the outside of the patient’s sole from bottom to top, turning to the inside as it nears the toes, and observing the changes in the toes. Its positive significance is indicative of damage to the pyramidal tracts in the central part of the brain. In the examination of Babinski’s sign, the patient lies flat on the bed, and the examiner, using a cotton swab stick or other small metal rod with a blunt tip, gently strokes the patient’s foot from below upward over the outside of the plantar aspect of the foot, turning medially at the base of the little toe. A positive sign is characterized by dorsiflexion of the big toe and fanning out of the rest of the toes. A positive Babinski sign suggests the presence of cone bundle damage. Common causes of a positive sign include cerebral infarction, cerebral hemorrhage, brain tumor, traumatic brain injury, acute transverse myelitis, and others. Patients with a positive Babinski’s sign are advised to seek prompt medical attention.