A patient with a cerebral infarction with a crooked mouth is considered to have a neurological deficit due to infarction of the local tissues of the brain, which can be seen in infarction of the cerebral hemispheres or the brainstem. Infarction of the cerebral hemisphere is due to damage to the fibers of the facial nerve and affects facial palsy. Most often, this is a central facial palsy, and the patient may show a loss of facial muscle movement below the eyebrows. For lesions of the brainstem, most often seen clinically as infarcts of the cerebral bridge, can present with facial palsy causing a distorted mouth. If the infarction of the brainstem is low and damages the lower nucleus of the facial nerve, peripheral facial palsy can also occur, which can manifest as a loss of movement of the lateral facial muscles. After the diagnosis is confirmed by head MRI, the treatment should be tailored to the cerebral infarction.