Itchy penis root inside may be caused by fungal or bacterial infection, mainly through the application of antifungal drugs or anti-bacterial drugs for treatment. 1. Anti-fungal drugs: after diagnosed as fungal infection through secretion examination, you can use clotrimazole ointment, dacronin ointment and other drugs for treatment, you can use 5% sodium bicarbonate for external washing every night, and change your underwear diligently. 2. Anti-bacterial drugs: people diagnosed with bacterial infection through secretion examination can be treated with cephalosporins or fluoroquinolones, cephalosporins can be used such as ceftazidime, cefixime, etc., and fluoroquinolones can be used such as levofloxacin, moxifloxacin and other drugs. All of the above drugs need to be used under the advice of a doctor, maintain a light diet during treatment, and keep the local hygiene dry and clean.