Treatment of secondary plasma cell leukemia includes supportive therapy, drug therapy, and surgery. 1. Supportive treatment: anemia and low hemoglobin can be treated with red blood cell transfusion and erythropoietin if necessary. Isotonic saline, calcitonin, bisphosphonates and other drugs can be used to treat hypercalcemia caused by secondary plasma cell leukemia. Patients with hyperuricemia may be treated with allopurinic acid. Patients with renal failure can undergo hemodialysis. 2. Drug therapy: chemotherapeutic drugs, targeted drugs, or combined use can be used separately. Chemotherapeutic drug treatment includes VAD program or combined treatment program, VAD program is vincristine, doxorubicin, dexamethasone, when the VAD program is not effective, combined treatment program such as vincristine, Zoerythromycin, cyclophosphamide, prednisolone can be used. 3. Surgery: If drug treatment is ineffective and the patient is in good general condition, autologous hematopoietic stem cell transplantation can be performed. If secondary plasma cell leukemia occurs, it is recommended to go to the hospital in time, and under the guidance of the physician to carry out regular treatment as soon as possible.