Cimetidine is not effective for appendicitis. Cimetidine is a drug that inhibits stomach acid and is an H2 receptor antagonist. The medication is taken to relieve symptoms such as stomach pain, acid reflux, and burning sensation in the stomach caused by excess stomach acid. Most appendicitis is caused by a bacterial infection and requires the administration of anti-infective drugs. Cimetidine, on the other hand, does not have an anti-infective effect on appendicitis. Appendicitis is related to the obstruction of the appendiceal lumen, bacterial invasion, and congenital malformation of the appendix. In most patients who develop appendicitis, it is caused by an infection of the appendix, which may cause an inflammatory response that leads to swelling and pain. The symptoms of appendicitis are complex and varied, and are more similar to other acute abdominal conditions, while metastatic abdominal pain is the main feature of appendicitis. Treatment of appendicitis is usually based on anti-infective medications such as cefmetazole and ceftriaxone. If combined with perforated appendix, peritonitis and other emergencies, surgery can be performed to remove the diseased appendix. Symptoms such as metastatic abdominal pain or paroxysmal or persistent abdominal distension are recommended to visit the general surgery department of the hospital in time.