If patients have headaches accompanied by aching limbs, there are usually several factors as follows: 1. Infectious factors, when the body is infected by bacteria, viruses, fungi or atypical pathogens, such as mycoplasma and chlamydia, the body will be released into the blood by the endotoxins of these bacteria, such as leukotrienes, bradykinin, prostacyclin, tumor necrosis factor, etc., which will lead to clinical symptoms and manifestations such as headaches and aching limbs. 2. If the patient drinks too much alcohol, the capillaries will be dilated due to acetaldehyde in alcohol, and the clinical symptoms and manifestations of typical headache and limb pain will appear. 3. Clinical symptoms and manifestations.