Glinides are one of the common hypoglycemic drugs. What is the mechanism of action? What are the characteristics of the pharmacokinetics? What are the adverse effects? What are the contraindications? These are the things that diabetic patients should know. What are the types of glinides and what are their mechanisms of action? Mechanism of action and indications of glinides I. Mechanism of action Stimulates insulin secretion from pancreatic beta cells, but the binding site is different from that of sulfonylureas, which can improve early insulin secretion. Indications Early postprandial hyperglycemic stage of type 2 diabetes or patients with mainly postprandial blood glucose elevation. It can be applied alone, or combined with metformin and insulin sensitizer. The pharmacokinetic characteristics of glinides 1. Rapid onset of action, 0-30 minutes. 2, peak time of 1 hour. 3.Short half-life, about 1 hour. 4, rapid metabolism, no active metabolites, 92% with bile excretion, only 8% by renal excretion, so it is suitable for mild renal insufficiency, elderly diabetic patients. D. Commonly used drugs in the class of glinolide 1, Repaglinide 2, Naglinide 3, Miglinide V. Dosage and usage of Repaglinide 1, the recommended starting dose (alone or in combination) 0.5mg, for new patients or HbA1c <8%. 1.0mg, 2.0mg, for those who have used other oral hypoglycemic drugs in the past or whose HbA1c is >8%. 2. Maximum dose: 4mg/time, 16mg/day. 3.Take the medication at mealtime or if the patient wants to take a meal, no meal is required. Six, the adverse reactions of Repaglinide class drugs 1, gastrointestinal reactions: diarrhea or vomiting, common. 2, hypoglycemia: low incidence, mild and limited to postprandial. 3.Some cases have mild and transient elevation of liver enzymes. 4.Basic weight may be slightly increased compared with that before treatment. VII. Contraindications to Repaglinide 1. Hypersensitivity to any of the components of Repaglinide. 2.Pregnant women and nursing mothers. 3.Patients with type 1 diabetes mellitus. 4.Patients with acute complications such as diabetic ketoacidosis. 5.Patients with severe hepatic or renal insufficiency. 6.In case of severe stress.