The quadruple solution for H. pylori eradication includes: first, PPI; second, bismuth preparation; third, two antibiotics. PPI is also called proton pump inhibitor, including omeprazole, lansoprazole, rabeprazole, estramiprazole, pantoprazole, etc. The most commonly used bismuth preparations are bismuth potassium citrate, bismuth-magnesium combination, bismuth-aluminum combination, the more widely used is bismuth potassium citrate, some patients will have stomach pain after taking this drug. Antibiotics include three kinds: amoxicillin, clarithromycin, metronidazole, and levofloxacin can be chosen for drug-resistant Helicobacter pylori.