Waking up in the middle of the night with pain in the urethra, the most likely cause of this condition is a stone falling from the kidney to the ureter, there will be sudden pain and frequent urination, there may also be hematuria, there may be nausea and vomiting when the pain is present. It is recommended that diclofenac pain suppositories 50mg should be given immediately to the anus, which can relieve the pain quickly. After the pain is relieved, it is recommended to go to the hospital for ultrasound examination of kidney, ureter and bladder, and routine urine examination, which can determine whether there are ureteral stones, and if there are, the size and number of stones and whether there is hydronephrosis can be determined. After finding the stones, we should decide how to treat them according to their size. For stones smaller than 0.5cm, drink more water, urinate more and take lithotriptic drugs; for stones larger than 0.5cm, extracorporeal shock wave lithotripsy should be used.