The main side effects of pantethine are mainly allergic reactions. Allergic reactions can lead to a number of symptoms in various systems, such as a generalized reactive heat sensation, headache, neurotic edema, cough, generalized skin maculopapular rash with pruritus, and urticaria. In severe cases, it can lead to circulatory dysfunction causing hypotension, reflex tachycardia, dyspnea, irritability, impaired consciousness and other shock manifestations. If not rescued in time may endanger the life of the patient, but of course the incidence of these serious allergic reactions is relatively low. The most common clinical side effects are headache and generalized reactive heat sensation, which mostly disappear on their own without special treatment.