Low back pain (LBP) is extremely common in clinical practice, and it is estimated that at least 70% of people in the Western developed world will experience LBP during their lifetime. Low back pain is the second leading cause of patient visits in the United States, after upper respiratory tract infections. The causes of low back pain are numerous, and in terms of its differential diagnosis, non-mechanical causes of low back pain such as tumors, infections, and arthritis account for only 1% of cases, while the most common are mechanical low back pain, including lumbar disc herniation (4%), spinal stenosis (3%), lumbar spondylolisthesis (2%), vertebral compression fracture (4%), lumbar isthmus fracture, intradiscal rupture or discogenic low back pain, and lumbar instability (these three together account for about 2%), progressive degeneration of intervertebral discs and small joints (often age-related, 10%), and the most common of these is idiopathic low back pain (70%), which is often clinically referred to as lumbar sprain and lumbar strain and often has no clear pathological anatomical evidence. In previous studies on low back pain, the more recognized risk factors by scholars include smoking, obesity, the elderly, women, heavy physical labor, sedentary jobs, high work stress, anxiety, and depression. The current studies on the association between exercise load and low back pain in daily work and life are either only cross-sectional studies (also known as current studies) or the follow-up period is too short to produce a higher grade of evidence-based medical evidence. The study included 4738 volunteers, ranging in age from 25 to 64 years, who were examined for low back pain at 5-year intervals beginning in 1993 and followed through the population for up to 15 years, with a total of three examinations as of 2007. At each examination, the physical load of daily work and life (e.g., incorrect posture, mechanical vibration, etc.) was measured by two separate questionnaires. Information from these questionnaires was pooled and then analyzed by multiple logistic regression according to gender, age, education, work status, body mass index (BMI), physical activity, and smoking. It was found that the prevalence of low back pain due to physical load did not change much, although 50% of the individuals experienced a significant change in physical load every 5 years. The option “incorrect posture” was selected by 7.2% of people in both questionnaires, 8.4% selected “incorrect posture” only in the first questionnaire, and 6.8% selected only in the second questionnaire. Of all the variables related to physical load, only “incorrect posture” was significantly associated with chronic low back pain. The risk of chronic low back pain was significantly increased in those who selected the “incorrect posture” option in both questionnaires. Interestingly, those who selected the “incorrect posture” option in only one questionnaire were strongly associated with persistent chronic low back pain. With this cohort study, the authors confirm that incorrect posture in daily physical activity is strongly associated with the development of chronic low back pain in the general population. This also reminds people, especially those who need to be sedentary for long periods of time, that avoiding improper posture and reducing pathological load on the lumbar spine can somehow prevent the occurrence of chronic low back pain. For patients who already suffer from chronic low back pain, it may also be possible to reduce the duration of symptoms.