Stage III prostate cancer is usually difficult to be cured, but it can be treated by surgery, hormone therapy, radiotherapy and so on, so as to prolong the survival time of patients and improve their quality of life. Prostate cancer is an epithelial malignant tumor that occurs in the prostate gland, which belongs to the common malignant tumors of male genitourinary system. Its etiology is not yet clear, and it may be caused by heredity, genetic changes, improper diet, obesity and other factors. Patients may have symptoms such as frequent urination, urinary urgency, difficulty in urination, accompanied by hematuria and hematospermia. It is generally difficult for patients with stage III prostate cancer, but they need to actively cooperate with doctors to take relevant treatment measures, such as traditional prostatectomy, laparoscopic prostatectomy, etc., or to take testicular resection, as well as follow the doctor’s instructions for oral bicalutamide, nilumet and other anti-androgenic drugs. Combined with chemotherapy and radiotherapy, comprehensive treatment measures are taken, and some patients can improve their quality of life after standardized drug treatment. Once diagnosed with stage III prostate cancer, patients need to consult the doctor in time for examination and early treatment.