According to the TNM staging of colorectal cancer combined with anatomical staging, two lymph node metastases in the middle stage of rectal cancer belong to stage III. The clinicopathologic staging of colorectal cancer is based on the International Union Against Cancer (UICC) Colorectal Cancer 2017 8th Edition TNM staging method: 1.T stands for primary tumor and Tx for primary tumor cannot be evaluated. No evidence of primary tumor could be found is indicated by T0; Tis is carcinoma in situ; T1: involvement of submucosal layer; T2: reaching the intrinsic muscularis propria; T3: has penetrated the intrinsic muscularis propria to the subplasma membrane or involved paracolic tissues of the colorectum; penetrated the dirty peritoneum is T4a, and invaded or adhered to other organs is T4b. 2.N is regional lymph node metastasis, Nx means unable to evaluate; the absence of regional lymph node metastasis is indicated by N0; N1 means there are 1~3 lymph nodes metastasis; and N2 represents the case of 4 or more lymph nodes metastasis. 3.M represents the situation of distant metastasis, Mx indicates that the presence or absence of distant metastasis cannot be estimated; M0 is the absence of distant metastasis; once there is distant metastasis, it is indicated by M1. According to the staging method, combined with the anatomical staging of mid-stage rectal cancer, at least the tumor invades the muscle layer of the intestinal wall; it can be known that mid-stage rectal cancer with two lymph node metastases belongs to stage III. Specifically, it should be evaluated systematically in relevant departments of hospitals after examination, and it is recommended to consult doctors as early as possible for diagnosis and treatment.